Sure, there's a visit to the medieval village of St. Emilion, now a UNESCO World Heritage Site, but vineyard-hopping is the main focus on Trek Travel's Bordeaux tour. There's even a day of oenology instruction at "Wine School," also in St. Emilion. Good thing, too, as you'll be hopping among some of the world's finest wine estates, including the legendary Château Lafite Rothschild. Should you decide to take part in a more challenging ride along the Dordogne River, Les Source des Caudalie, a pioneer in vinotherapy and your hotel for two nights, offers a variety of merlot baths and massages.

With its stunning castles and excellent vineyards and restaurants, Loire Valley is a natural choice for DuVine Adventures. The bike company specializes in "good eating, drinking, sleeping and biking," and this itinerary includes a stop at Château de Villandry, known for its mazelike gardens, and Monmousseaux's 7.5-mile troglodyte cellar tunnels where you can observe the art of making crémant, or sparkling wine. The accommodations like Château Chissay, a former residence for kings and queens, are suitably regal.

Home of the 2006 Olympic Winter Games and the birthplace of the slow food movement, Piedmonte is a great place for foodie cyclists. You'll enjoy rides through Moscato country (famous for its sweet spumante wine) as well as Santo Stefano Belbo and the wine towns of Asti, Barbaresco and Barolo. Highlights include wine tastings, a picnic on the grounds of a 17th-century castle and the opportunity to sample fresh cheeses, hazelnuts and the famous truffles of Langle. Lodging is at Antico Podere Propano, a traditional Piedmontese farmhouse, the Villa Beccaris, an 18th-century wine estate, and the luxury Relais San Maurizio, a former Franciscan monastery.

For more information: Backroads

© DuVine Adventures

Tuscany with DuVine Adventures

Tuscany's cypress-lined roads and sprawling vineyards and hills make it ideal biking and wine-touring country. You can do both on a trip with DuVine Adventures, whose founder Andy Levine arranges private tastings and meals with expert sommeliers and gourmands. For the more challenging bike moments, such as a six-mile downhill ride on the shoulder of Monte Amiata, the highest peak in Tuscany, he also provides a van. Accommodations are small, intimate properties with interesting histories and amazing cellars; one was the retreat of a former noble, another is a converted 15th-century monastery.

For more information: DuVine Adventures

Napa and Sonoma have more vineyards, but for bikers, Santa Barbara's wine country stands out. Mount Figueroa, after all, is where Lance Armstrong trained. On Butterfield & Robinson's trip, hardcore riders will get a chance to follow in the bike legend's tire tracks; those looking for gentler experience will find plenty of flatter trails along the region's coastal roads as well as a number of great restaurants and boutique wineries. Lodging is at the Alisal Guest Ranch, a chic working cattle ranch in Solvang—otherwise known as the "Little Denmark of California"—and the classic Four Seasons Biltmore in Montecito.